https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36332 Thu 24 Mar 2022 11:36:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33468 Thu 24 Mar 2022 11:35:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19006 50 of 11.4 μM (two orders of magnitude more potent than naproxen). Selectivity of 3a was investigated against a panel of three tumor and one normal colon cell lines and showed up to six times less toxicity against normal colonocytes. Compound 3a was shown to induce dose-dependent apoptosis of HT116 colon tumor cells as evidenced by measuring the activity of caspases-3 and 7. None of the synthesized compounds showed activity against COX-1 or COX-2 isozymes, confirming a COX-independent mechanism of action. Compound 3k was found to have no ulcerogenic effect in rats as indicated by electron microscope scanning of the stomach after oral administration. A pharmacophore model was developed for elucidating structure–activity relationships and subsequent chemical optimization for this series of compounds as colorectal cancer chemopreventive drugs.]]> Sat 24 Mar 2018 08:05:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27326 Sat 24 Mar 2018 07:38:36 AEDT ]]>